Papers:
- Original paper that first introduced the concept that the cytoplasmic mRNA decay factors foster transcription (Haimovich et al. Cell 2013).
- The function of mRNA decay factors in transcription initiation and elongation is describe in Fischer et al., JBC 2019.
- The cytoplasmic mRNA decay pathway of ~50% of the yeast mRNAs starts in the nucleus and linked to transcription (Chattopadhyay et al Nat comm. 2022)
- The nucleocytoplasmic shuttling of some mRNA decay factors is controlled by the decaying RNA, thus linking mRNA decay to mRNA synthesis (Chattopadhyay et al Nat comm 2022 )
- A circular life of a zinc-finger protein that regulates the lifecycle of specific family of mRNA is described in Kelbert et al. eLife 2024.
- The concept is Reviewed in Haimovich et al., BBA 2013
The mRNA life is circular as synthesis and degradation are mediated by a single multifactorial mechanism, the “synthegradosome“, which shuttles between the chromatin and the cytoplasm (Haimovich et al., 2013
).