“mRNA coordinator” concept


Papers dealing with mRNA coordinators





The mRNA coordination idea was first discussed in our paper Harel-Sharvit et al. 2010. See the section “Rpb4/7 Coordinates the mRNA Lifecycle” in the Discussion of this paper.


Rpb4/7 mediates mRNA synthesis, transport, translation, and decay through ‘‘mRNA imprinting.’’ It undergoes more than 100 possible combinations of posttranslational modifications that change temporally and spatially. These modifications seem to represent a language by which the above stages of the mRNA life cycle  communicate.